Vidal-Rosas, EE;
Billings, SA;
Chico, T;
Coca, D;
(2016)
Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography.
Journal of Biomedical Optics
, 21
(6)
, Article 066012. 10.1117/1.JBO.21.6.066012.
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Abstract
The application of near-infrared spectroscopy (NIRS) to assess microvascular function has shown promising results. An important limitation when using a single source-detector pair, however, is the lack of depth sensitivity. Diffuse optical tomography (DOT) overcomes this limitation using an array of sources and detectors that allow the reconstruction of volumetric hemodynamic changes. This study compares the key parameters of postocclusive reactive hyperemia measured in the forearm using standard NIRS and DOT. We show that while the mean parameter values are similar for the two techniques, DOT achieves much better reproducibility, as measured by the intraclass correlation coefficient (ICC). We show that DOT achieves high reproducibility for muscle oxygen consumption (ICC: 0.99), time to maximal HbO2 (ICC: 0.94), maximal HbO2 (ICC: 0.99), and time to maximal HbT (ICC: 0.99). Absolute reproducibility as measured by the standard error of measurement is consistently smaller and close to zero (ideal value) across all parameters measured by DOT compared to NIRS. We conclude that DOT provides a more robust characterization of the reactive hyperemic response and show how the availability of volumetric hemodynamic changes allows the identification of areas of temporal consistency, which could help characterize more precisely the microvasculature.
| Type: | Article |
|---|---|
| Title: | Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/1.JBO.21.6.066012 |
| Publisher version: | https://doi.org/10.1117/1.JBO.21.6.066012 |
| Language: | English |
| Additional information: | Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.21.6.066012] |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemical Research Methods, Optics, Radiology, Nuclear Medicine & Medical Imaging, Biochemistry & Molecular Biology, diffuse optical tomography, near-infrared spectroscopy, reproducibility, NEAR-INFRARED SPECTROSCOPY, PERIPHERAL VASCULAR-DISEASE, MEASUREMENT DENSITY-FUNCTIONS, TIME-RESOLVED SPECTROSCOPY, FINITE-ELEMENT-METHOD, BLOOD-FLOW, SKELETAL-MUSCLE, NONINVASIVE METHODS, HEALTHY-VOLUNTEERS, ARTERIAL-DISEASE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10072440 |
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