O'Cathail, Sean M;
Adams, Richard;
Hawkins, Maria A;
Sebag-Montefiore, David;
Marijnen, Corrie AM;
Fokas, Emmanouil;
(2023)
Patient-reported outcomes in PROSPECT trial (Alliance N1048) – FOLFOX is not a panacea.
Clinical and Translational Radiation Oncology
, 43
, Article 100672. 10.1016/j.ctro.2023.100672.
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Abstract
The PROSPECT was a randomized phase III trial that included patients with resectable rectal cancer (clinical stage cT2-3N+ or cT3N0). The trial aimed to test the hypothesis that pre-operative chemotherapy consisting of 6 cycles of FOLFOX given over a 12-week period, followed by total mesorectal excision (TME) surgery, was non-inferior to pre-operative long-course chemoradiotherapy (CRT). The primary endpoint of the study was disease-free survival (DFS), and patients were also monitored for other relevant oncological outcomes such and health-related quality of life (HRQoL) using patient-reported outcome (PRO) tools [1, 2].
| Type: | Article |
|---|---|
| Title: | Patient-reported outcomes in PROSPECT trial (Alliance N1048) – FOLFOX is not a panacea |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ctro.2023.100672 |
| Publisher version: | https://doi.org/10.1016/j.ctro.2023.100672 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Rectal cancer; Trials; PROSPECT; QoL; Radiotherapy; Chemotherapy; Overtreatment; Guidelines |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10177185 |
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