Lemieux, L.;
Salek-Haddadi, A.;
Lund, T.;
Laufs, H.;
Carmichael, D.;
(2007)
Modelling large motion events in fMRI studies of patients with epilepsy.
In: Gore, J., (ed.)
Proceedings of the International School on Magnetic Resonance and Brain Function Workshop: Magnetic Resonance Combined with Electrophysiology and Molecular and Pharmaceutical Action for the Study of Brain Function, Erice, Italy 21– 28 May 2006:.
(pp. pp. 894-901).
Elsevier B.V.: Amsterdam, The Netherlands.
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Abstract
EEG-correlated fMRI can provide localisation information on the generators of epileptiform discharges in patients with focal epilepsy. To increase the technique's clinical potential, it is important to consider ways of optimising the yield of each experiment while minimizing the risk of false-positive activation. Head motion can lead to severe image degradation and result in false-positive activation and is usually worse in patients than in healthy subjects. We performed general linear model fMRI data analysis on simultaneous EEG–fMRI data acquired in 34 cases with focal epilepsy. Signal changes associated with large inter-scan motion events (head jerks) were modelled using modified design matrices that include ‘scan nulling’ regressors. We evaluated the efficacy of this approach by mapping the proportion of the brain for which F-tests across the additional regressors were significant. In 95% of cases, there was a significant effect of motion in 50% of the brain or greater; for the scan nulling effect, the proportion was 36%; this effect was predominantly in the neocortex. We conclude that careful consideration of the motion-related effects in fMRI studies of patients with epilepsy is essential and that the proposed approach can be effective.
Type: | Proceedings paper |
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Title: | Modelling large motion events in fMRI studies of patients with epilepsy |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1016/j.mri.2007.03.009 |
Publisher version: | http://dx.doi.org/10.1016/j.mri.2007.03.009 |
Language: | English |
Additional information: | Paper presented at the Magnetic Resonance Combined with Electrophysiology and Molecular and Pharmaceutical Action for the Study of Brain Function Workshop, Erice, Italy 21– 28 May 2006 |
Keywords: | Large motion events, epilepsy, fMRI, modelling |
UCL classification: | UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
URI: | https://discovery.ucl.ac.uk/id/eprint/20282 |
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