The Library
A survey of molecular communication in cell biology : establishing a new hierarchy for interdisciplinary applications
Tools
Bi, Dadi, Almpanis, Apostolos, Noel, Adam, Deng, Yansha and Schober, Robert (2021) A survey of molecular communication in cell biology : establishing a new hierarchy for interdisciplinary applications. IEEE Communications Surveys & Tutorials, 23 (3). pp. 1494-1545. doi:10.1109/COMST.2021.3066117 ISSN 1553-877X.
|
PDF
WRAP-survey-molecular-communication-cell-biology-establishing-new-hierarchy-interdisciplinary-applications-Noel-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (24Mb) | Preview |
|
PDF
MC_Survey_final.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (24Mb) |
Official URL: https://doi.org/10.1109/COMST.2021.3066117
Abstract
Molecular communication (MC) engineering is inspired by the use of chemical signals as information carriers in cell biology. The biological nature of chemical signaling makes MC a promising methodology for interdisciplinary applications requiring communication between cells and other microscale devices. However, since the life sciences and communications engineering fields have distinct approaches to formulating and solving research problems, the mismatch between them can hinder the translation of research results and impede the development and implementation of interdisciplinary solutions. To bridge this gap, this survey proposes a novel communication hierarchy for MC signaling in cell biology and maps phenomena, contributions, and problems to the hierarchy. The hierarchy includes: 1) the physical propagation of cell signaling at the Physical Signal Propagation level; 2) the generation, reception, and biochemical pathways of molecular signals at the Physical and Chemical Signal Interaction level; 3) the quantification of physical signals, including macroscale observation and control methods, and conversion of signals to information at the Signal-Data Interface level; 4) the interpretation of information in cell signals and the realization of synthetic systems to store, process, and communicate molecular signals at the Local Data Abstraction level; and 5) applications relying on communication with MC signals at the Application level. To further demonstrate the proposed hierarchy, it is applied to case studies on quorum sensing, neuronal signaling, and communication via DNA. Finally, several open problems are identified for each level and the integration of multiple levels. The proposed hierarchy provides language for communication engineers to study and interface with biological systems, and also helps biologists to understand how communications engineering concepts can be exploited to interpret, control, and manipulate signaling in cell biology.
Item Type: | Journal Article | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software Q Science > QH Natural history Q Science > QR Microbiology T Technology > TK Electrical engineering. Electronics Nuclear engineering |
||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||||||
Library of Congress Subject Headings (LCSH): | Cytology, Cytology -- Analysis, Molecular communication (Telecommunication) | ||||||||||||
Journal or Publication Title: | IEEE Communications Surveys & Tutorials | ||||||||||||
Publisher: | IEEE | ||||||||||||
ISSN: | 1553-877X | ||||||||||||
Official Date: | September 2021 | ||||||||||||
Dates: |
|
||||||||||||
Volume: | 23 | ||||||||||||
Number: | 3 | ||||||||||||
Page Range: | pp. 1494-1545 | ||||||||||||
DOI: | 10.1109/COMST.2021.3066117 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 22 March 2021 | ||||||||||||
Date of first compliant Open Access: | 22 March 2021 | ||||||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year