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Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis
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Silio, Virginia, Redondo-Munoz, Javier and Carrera, Ana C. (2012) Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis. Molecular Biology of the Cell, 23 (23). pp. 4526-4542. doi:10.1091/mbc.E12-05-0371 ISSN 1939-4586.
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Official URL: http://dx.doi.org/10.1091/mbc.E12-05-0371
Abstract
Class IA phosphoinositide 3-kinases (PI3K) are enzymes composed of a p85 regulatory and a p110 catalytic subunit that control formation of 3-poly-phosphoinositides (PIP3). The PI3K pathway regulates cell survival, migration, and division, and is mutated in approximately half of human tumors. For this reason, it is important to define the function of the ubiquitous PI3K subunits, p110α and p110β. Whereas p110α is activated at G1-phase entry and promotes protein synthesis and gene expression, p110β activity peaks in S phase and regulates DNA synthesis. PI3K activity also increases at the onset of mitosis, but the isoform activated is unknown; we have examined p110α and p110β function in mitosis. p110α was activated at mitosis entry and regulated early mitotic events, such as PIP3 generation, prometaphase progression, and spindle orientation. In contrast, p110β was activated near metaphase and controlled dynein/dynactin and Aurora B activities in kinetochores, chromosome segregation, and optimal function of the spindle checkpoint. These results reveal a p110β function in preserving genomic stability during mitosis.
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QR Microbiology | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Chromosomes, Mitosis | ||||||
Journal or Publication Title: | Molecular Biology of the Cell | ||||||
Publisher: | American Society for Cell Biology | ||||||
ISSN: | 1939-4586 | ||||||
Official Date: | 1 December 2012 | ||||||
Dates: |
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Volume: | 23 | ||||||
Number: | 23 | ||||||
Number of Pages: | 17 | ||||||
Page Range: | pp. 4526-4542 | ||||||
DOI: | 10.1091/mbc.E12-05-0371 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Funder: | Spanish Association Against Cancer, Spain. Ministerio de Ciencia e Innovación, Network of Cooperative Research | ||||||
Grant number: | SAF2007-63624, SAF2010-21019, RD07/0020/2020 |
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