Repository landing page
Assessment of optic disc and ganglion cell layer in diabetes mellitus type 2
Abstract
The purpose of this study was to compare the optic disc parameters, retinal nerve fiber (RNFL), and macular ganglion cell layers between patients with diabetes mellitus (DM) type 2 and healthy controls. In this cross-sectional study, 69 eyes of 69 diabetic patients without diabetic retinopathy and 47 eyes of 47 healthy controls were included. Optic disc parameters (i.e., rim area, disc area, cup to disc ratio, cup volume), RNFL, and macular ganglion cell-inner plexiform layers (GCL+IPL) thickness were measured by means of spectral domain optical coherence tomography. There were not statistically significant differences between the diabetic patients and healthy controls in terms of RNFL thickness (P=.32), rim area (P=.20), disc area (P=.16), cup volume (P=.12), and average macular GCL+IPL thickness (P=.11). Nevertheless, binocular RNFL thickness symmetry percentage (P=.03), average cup to disc ratio (P=.02), and superior-nasal macular GCL+IPL thickness (P=.04) were statistically significantly different in the diabetic and control groups. Diabetic patients without retinopathy have more binocular RNFL thickness asymmetry, higher cup to disc ratio, and thinner sectoral macular GCL+IPL when compared to healthy controls. Our results may support the statement that DM causes inner retinal neurodegenerative changes. © 2017 the Author(s). Published by Wolters Kluwer Health, Inc- Article
- diabetes mellitus
- HbA1c
- macular ganglion cell layer
- optic disc
- retinal nerve fiber layer
- hemoglobin A1c
- adult
- aged
- Article
- binocular vision
- controlled study
- cross-sectional study
- diabetic patient
- diabetic retinopathy
- disease duration
- female
- hemoglobin blood level
- human
- macular thickness
- major clinical study
- male
- non insulin dependent diabetes mellitus
- optic disk
- optical coherence tomography device
- priority journal
- retina ganglion cell
- retinal nerve fiber layer thickness
- spectral domain optical coherence tomography
- comparative study
- diagnostic imaging
- middle aged
- optical coherence tomography
- organ size
- Adult
- Aged
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
- Diabetic Retinopathy
- Female
- Humans
- Male
- Middle Aged
- Optic Disk
- Organ Size
- Retinal Ganglion Cells
- Tomography, Optical Coherence