Repository landing page
research
T-ALL and thymocytes : a message of noncoding RNAs
Abstract
In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development- journalArticle
- info:eu-repo/semantics/article
- info:eu-repo/semantics/publishedVersion
- Biology and Life Sciences
- Medicine and Health Sciences
- T-ALL
- Thymocytes
- LncRNA
- MicroRNA
- ACUTE LYMPHOBLASTIC-LEUKEMIA
- COMPETING ENDOGENOUS RNA
- TUMOR-SUPPRESSOR
- CELL DEVELOPMENT
- GENE-EXPRESSION
- MICRORNA BIOGENESIS
- GLUCOCORTICOID-RECEPTOR
- MICROPROCESSOR COMPLEX
- SIGNATURES DEFINE
- MIRNA EXPRESSION