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To evaluate the phenolic profile and biological activity of the Algerian Sahara plant Acacia tortilis (Forssk.)
Hayne ssp. raddiana decoction and 80% ethanolic extracts were studied. Chromatographic profiling indicated
the presence of 36 phenolic compounds, including gallic acid esterified derivatives, galloylquinic derivatives and
flavan-3-ols galloyl derivatives. Both extracts showed significant cytotoxic activity and a potent anti-inflammatory
activity. They were effective against several multi-drug resistant bacteria, namely methicillin-resistant
Staphylococcus aureus (MRSA). To understand the possible mechanism of action of MRSA inhibition activity,
an in silico docking analysis was done using a virtual library of the 36 determined phenolic compounds
against penicillin-binding protein (PBP2a), a protein known to be involved in MRSA resistance to β-lactam
antibiotics. A. tortilis extracts showed interesting biological activities and the phenolic compounds found could
be an interesting starting point for the development of cytotoxic and anti-inflammatory drugs and especially
anti-MRSA antibiotics.The authors are grateful to the Foundation for Science and
Technology (FCT, Portugal) for financial support through national
funds FCT/MCTES to CIMO (UIDB/00690/2020). L. Barros and R. C.
Calhelha thank the national funding by the FCT, P.I., through the institutional
scientific employment program-contract for their contracts.
M. Carocho also thanks the project ValorNatural for his research contract.
The authors are also grateful to the FEDER-Interreg España-
Portugal programme for financial support through the project
0377_Iberphenol_6_E.info:eu-repo/semantics/publishedVersio
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