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oaioai:digitalcommons.dartmouth.edu:facoa-4836

A Cascade of Multiple Proteins and Lipids Catalyzes Membrane Fusion

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Publication date
10 January 2017
Publisher
Dartmouth Digital Commons
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    Abstract

    Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar wedge domains into the bilayers, initiating the lipid rearrangements of fusion

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    Last time updated on 17/10/2019

    This paper was published in Dartmouth Digital Commons (Dartmouth College).

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