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oaioai:doaj.org/article:13aaeef7b8c0416c8bf8f42f82757fbf

A novel approach to treating osteoarthrosis as a chronic inflammatory disease

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Publication date
1 June 2013
Publisher
'IMA Press, LLC'
Doi

    Abstract

    A large role in the pathogenesis of osteoarthrosis (OA) is assigned to proinflammatory cytokines, such as interleukin 1 (IL1) and tumor necrosis factor-α, which activate catabolic processes in the cartilaginous tissue and subchondral bone. Diacerein is a medication that is able to block IL1 receptors, to lower the activity of metalloproteinases and nitric oxide, and thus to prevent joint inflammation and destruction in OA

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    Last time updated on 09/08/2016

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