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The N-myc oncogene was first identified as an amplified DNA element
with homology to c-myc in human neuroblastoma. Since this initial
observation, amplification of N-myc has also been observed in other types
of human cancer, predominantly in retinoblastoma and small cell lung
cancer. The apparent role of the N-myc oncogene in neuroblastoma
oncogenesis is unusual in that amplification of N-myc is hardy ever observed
in primary non-metastatic neuoblastoma. Rather, amplification of
N-myc has been found predominantly in advanced, widely metastatic
neuroblastoma. This close association between N-myc amplification
and metastatic ability suggests that a relationship exists between these
two phenomena, namely that N-myc over-expression is responsible for
the increased metastatic ability of the N-myc-amplified tumor cells
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