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In anorexia nervosa (AN), hyperactivity is observed in about
80% of patients and has been associated with low leptin levels in the
acute stage of AN and in anorexia animal models. To further understand
the importance of this correlation in AN, we investigated the relationship
between hypoleptinaemia and hyperactivity in AN patients longitudinally
and assessed their predictive value for recovery.
Body weight, activity levels, and serum leptin levels were assessed
in adolescents and adult AN patient groups at the start and during
treatment, up to a year. In the adolescent group, initial leptin and activity
levels were correlated. This negative correlation changes over time
into a positive correlation with physiological recovery. Treatment outcome
in both groups could be predicted by initial BMI and leptin levels
but not by activity levels. No major relationship of activity with the
course of recovery was detected, suggesting that in contrast to the acute
stage of the disease, leptin and activity levels during the recovery process
are dissociated
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