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oaioai:dspace.xmu.edu.cn:2288/18020

血管内皮细胞生长抑制因子的研究进展

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30 August 2006
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Abstract

血管内皮细胞生长抑制因子(vascularendothelialgrowthinhibitor,VEGI)是一种新型的血管内皮细胞生长抑制因子,属于TNF超家族,是Ⅱ型跨膜蛋白。重组VEGI不仅可以抑制内皮细胞增殖和诱导血管内皮细胞凋亡,而且可阻止新生血管生成,从而产生抗肿瘤生长的作用。VEGI作为一个内皮细胞产生的血管生成负调控因子可激活JNK、P38MAPA及胱冬肽,也可激活NF-κB,从而诱导内皮细胞的凋亡。VEGI的N段部分缺失可影响其生物活性,具有重要的病理生理意义,在肿瘤生物治疗方面有很大的应用前景

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Xiamen University Institutional Repository

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This paper was published in Xiamen University Institutional Repository.

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