Knowledge-based grouping of canonical pathways that were significantly enriched for CAD genetic loci.

Ville-Petteri Mäkinen (74272); Mete Civelek (599730); Qingying Meng (599731); Bin Zhang (64682); Jun Zhu (84054); Candace Levian (599732); Tianxiao Huan (599733); Ayellet V. Segrè (114771); Sujoy Ghosh (51427); Juan Vivar (599734); Majid Nikpay (599735); Alexandre F. R. Stewart (137807); Christopher P. Nelson (145678); Christina Willenborg (147937); Jeanette Erdmann (44256); Stefan Blakenberg (599736); Christopher J. O'Donnell (183188); Winfried März (106288); Reijo Laaksonen (172950); Stephen E. Epstein (256169); Sekar Kathiresan (60585); Svati H. Shah (268000); Stanley L. Hazen (230475); Muredach P. Reilly (206360); Aldons J. Lusis (108077); Nilesh J. Samani (60118); Heribert Schunkert (44257); Thomas Quertermous (94604); Ruth McPherson (34390); Xia Yang (46748); Themistocles L. Assimes (111675)

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Knowledge-based grouping of canonical pathways that were significantly enriched for CAD genetic loci.

Abstract

<p>The enrichment score was defined as the mean of negative log-transformed Kolmogorov-Smirnov and Fisher P-values for over-representation of high-ranking GWAS SNPs among the eSNPs that affect the expression of the pathway member genes. The number in parentheses in the first column indicates the number of CAD-associated pathways (detailed in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004502#pgen.1004502.s004" target="_blank">Table S1</a>).</p><p>*FDR<20% in Stage 1 and 2 respectively, and FDR<5% in combined Stage 1 & 2.</p

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Last time updated on 12/02/2018

This paper was published in FigShare.

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