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Schematic representation of the contribution of SslE to <i>E.coli</i> pathogenesis.
Abstract
<p>Gut mucus forms two layers, an inner firm mucus layer devoid of bacteria, and an outer layer that is not sterile and is a major habitat for commensal bacteria. <i>E. coli</i> can penetrate this barrier through the SslE-mediated enzymatic degradation of the mucus, targeting epithelial cells. This interaction will eventually lead to IL-8 release and neutrophils recruitment.</p- Image
- Figure
- Biological Sciences
- coli access
- mucosal barrier
- target cells
- Pathogenic E
- neutrophil recruitment
- growth rate postulating
- colonization factor favouring E
- Host Cells SslE
- mucin substrates
- mucus favouring bacteria adhesion
- il
- Host cells
- coli Exploits SslE Mucinase Activity
- SslE expression
- coli penetration
- vaccine candidate
- coli fitness