Effects of the AA/PGE₂ pathway on the ELF-EMF exposure-induced increase in <i>I</i>_Na in cerebellar GCs.

Abstract

<p>(A) PGE₂ release from cerebellar GCs exposed to 1 mT ELF-EMF for various lengths of time. The data are from three and four independent experiments, respectively. *, <i>P</i>< 0.05 compared to the corresponding control using Student’s <i>t</i>-test. (B) Intracellular AA levels in cerebellar GCs exposed to 1 mT ELF-EMF for various lengths of time. The data are from three and four independent experiments, respectively. *, <i>P</i>< 0.05 compared to the corresponding control using Student’s <i>t</i>-test. (C) Current traces show the inhibitory effects of the COX-2 inhibitors flufenamaic acid (FA) and niflumic acid (NA) on the increase in <i>I</i>_Na induced by 60 minutes of exposure to a 1 mT ELF-EMF. (D) Statistical analysis of the effects of FA and NA on the increase in <i>I</i>_Na induced by a 60-minute exposure to a 1 mT ELF-EMF. (E) Statistical analysis of the effects of FA and NA on PGE₂ release induced by a 60-minute exposure to a 1 mT ELF-EMF.</p