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Retromer-associated actin regulators colocalize with CCV actin patches.
Abstract
<p><b>(A and B)</b> CCV actin patches colocalize with Arp3, cortactin, WASH, and FAM21. The retromer protein VPS35 also colocalizes with patches whereas N-WASP does not. Vero cells at 3 dpi were immunostained for the indicated proteins. Histogram depicts the means ± SD of ≥ 60 cells for at least 3 independent experiments. Statistical significance was determined using Student’s t-test (****<i>P</i> <0.0001). Colocalization was determined using Pearson’s correlation coefficient. NMII, <i>C</i>. <i>burnetii</i> Nine Mile phase II strain. Scale bar, 5 μm.</p- Image
- Figure
- Biophysics
- Biochemistry
- Microbiology
- Cell Biology
- Genetics
- Molecular Biology
- Cancer
- Infectious Diseases
- CCV formation
- actin patches
- CCV actin patches
- actin filaments
- Arp
- cationic-independent mannose -6-phosphate receptor
- glucose transporter 1
- GLUT
- SNARE
- Filamentous actin patches
- CI-M 6PR
- CCV membrane
- HOPS
- host retromer function
- VPS 35
- knockout mouse embryo fibroblasts
- VPS 29
- CK
- VAMP
- FAM
- burnetii type 4 B secretion
- pathogen growth Coxiella burnetii