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Switchable slow cellular conductances determine robustness and tunability of network states
Abstract
<div><p>Neuronal information processing is regulated by fast and localized fluctuations of brain states. Brain states reliably switch between distinct spatiotemporal signatures at a network scale even though they are composed of heterogeneous and variable rhythms at a cellular scale. We investigated the mechanisms of this network control in a conductance-based population model that reliably switches between active and oscillatory mean-fields. Robust control of the mean-field properties relies critically on a switchable negative intrinsic conductance at the cellular level. This conductance endows circuits with a shared cellular positive feedback that can switch population rhythms on and off at a cellular resolution. The switch is largely independent from other intrinsic neuronal properties, network size and synaptic connectivity. It is therefore compatible with the temporal variability and spatial heterogeneity induced by slower regulatory functions such as neuromodulation, synaptic plasticity and homeostasis. Strikingly, the required cellular mechanism is available in all cell types that possess T-type calcium channels but unavailable in computational models that neglect the slow kinetics of their activation.</p></div- Image
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- Biophysics
- Cell Biology
- Genetics
- Molecular Biology
- Neuroscience
- Biotechnology
- Infectious Diseases
- Environmental Sciences not elsewhere classified
- Biological Sciences not elsewhere classified
- Mathematical Sciences not elsewhere classified
- Physical Sciences not elsewhere classified
- Information Systems not elsewhere classified
- brain states
- oscillatory mean-fields
- synaptic connectivity
- Robust control
- spatiotemporal signatures
- T-type calcium channels
- mechanism
- network size
- population rhythms
- network scale
- conductance-based population model
- cell types
- network states Neuronal information processing
- mean-field properties
- Brain states
- network control
- synaptic plasticity