Recent developments in polymer microfluidic devices with capillary electrophoresis and electrochemical detection

Abstract

We review recent work on the development of polymer microfluidic devices using capillary electrophoresis (CE) for fluid driving and separation and electrochemical detection (ED). A variety of commonly used off-chip and integrated electrochemical detection approaches, including amperometric, conductimetric and potentiometric detection approaches, have been given. We describe fabrication approaches for the creation of microfluidic architecture in a polymer substrate and electrode integration. The methods for polymer surface modification to enhance the microfluidic device properties are also described as well as developments in power supply for the creation of a robust CE-ED microfluidic device system. A variety of applications are described for the CE-ED systems