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oaioai:idus.us.es:11441/65006

Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains

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Publication date
1 July 1998
Publisher
'American Society for Microbiology'

Abstract

The intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.Comisión Interministerial de Ciencia y Tecnología PB96-019

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idUS. Depósito de Investigación Universidad de Sevilla

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oaioai:idus.us.es:11441/65006
Last time updated on 03/12/2017

This paper was published in idUS. Depósito de Investigación Universidad de Sevilla.

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