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oaioai:iris.uniroma1.it:11573/1211475

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

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Publication date
1 January 2018
Publisher
Doi

    Abstract

    Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We previously reported in lung cancer that CSCs maintenance is due to altered lipid metabolism and dependent upon Stearoyl-CoA-desaturase (SCD1)-mediated upregulation of YAP and TAZ. On this ground, we investigated the role of SCD1 in melanoma CSCs

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    Archivio della ricerca- Università di Roma La Sapienza

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    Last time updated on 18/03/2019

    This paper was published in Archivio della ricerca- Università di Roma La Sapienza.

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