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Radioresistance in lung cancer: a molecular approach
Abstract
Lung cancer represents one-quarter of the deaths caused by cancer. Despite the advances in treatments, chemo and radiotherapy remain the foundation of treatment for this disease, and the survival rate is still at 10%, mainly due to the recurrences after treatment. Tumors that re-emerge after a radiation treatment are usually radioresistant and challenging to treat. This research shows that lung cancer cells that have survived treatment with radiation therapy show characteristics of cancer stem cells and epithelial to mesenchymal transition. Moreover, radioresistant non-small cell lung cancer exhibited alterations of critical prosurvival signaling pathways, higher expression and activation of DNA repair genes, and altered expression of cytokines and receptors- doctoral thesis
- lung cancer
- HSP90
- radioresistance
- DNA repair
- radiation
- cancer stem cells
- epithelialmesenchymal transition
- Materias::Investigaci贸n::24 Ciencias de la vida::2407 Biolog铆a celular::240701 Cultivo celular
- Materias::Investigaci贸n::32 Ciencias m茅dicas::3207 Patolog铆a::320713 Oncolog铆a
- Materias::Investigaci贸n::32 Ciencias m茅dicas::3201 Ciencias cl铆nicas::320112 Radioterapia