Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia

Abstract

Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke. This paper aims to assess the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia. To achieve this objective, the literature was reviewed, randomized control tests were analyzed, and a systematic review was performed. The risk of developing cerebral ischemia was found to be reduced in hypercholesterolemic patients and patients with a history of cerebrovascular disease. However, it is unknown whether this reduction in incidence is a result of the drug, which reduces low-density lipoprotein levels in the blood, or to statins’ pleotropic effects on the vascular endothelium. Since their discovery, statins have proven to be beneficial in controlling cholesterol blood levels. Moreover, statins have been shown to have pleotropic effects after a certain period of use, one of which is lowering ischemic stroke incidence in hypercholesterolemic patients. Most recently, statins have been found to lower systolic blood pressure. It is not yet clear whether it has a significant effect on mortality or whether or not it is linked to statins