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Control Across Scales by Positive and Negative Feedback
Abstract
peer reviewedFeedback is a key element of regulation, as it shapes the sensitivity of a process to its environment. Positive feedback upregulates, and negative feedback downregulates. Many regulatory processes involve a mixture of both, whether in nature or in engineering. This article revisits the mixed-feedback paradigm, with the aim of investigating control across scales. We propose that mixed feedback regulates excitability and that excitability plays a central role in multiscale neuronal signaling. We analyze this role in a multiscale network architecture inspired by neurophysiology. The nodal behavior defines a mesoscale that connects actuation at the microscale to regulation at the macroscale. We show that mixed-feedback nodal control provides regulatory principles at the network scale, with a nodal resolution. In this sense, the mixed-feedback paradigm is a control principle across scales- journal article
- http://purl.org/coar/resource_type/c_6501
- info:eu-repo/semantics/article
- peer reviewed
- excitability
- feedback control
- multiscale control
- neuronal networks
- positive and negative feedback
- ultrasensitivity
- Artificial Intelligence
- Human-Computer Interaction
- Control and Systems Engineering
- Engineering (miscellaneous)
- Management, Monitoring, Policy and Law
- Geography, Planning and Development
- Engineering, computing & technology
- Ingénierie, informatique & technologie