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The ZIKA virus (ZIKV) codes for the NS5 protein, which is known as a potent anatagonist specific for interphase signaling (INF). ZIKV NS5 has been associated with proteasomal degradation of the signal transducer and activator of transcription 2 (STAT2), although the complete mechanism is still unknown as experimental studies suggest that domains other than Mtase contribute to degradation.El virus ZIKA (ZIKV) codifica para la proteína NS5, la cual se conoce como un anatagonísta potente y específico de la señalización de interfetón (INF). ZIKV NS5, se ha asociado con la degradación proteosomal del transductor de señal y el activador de la transcripción 2 (STAT2), aunque el mecanismo completo aún se desconoce ya que los estudios experimentales sugieren que dominios diferentes a Mtase contribuyen a la degradacion
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