We are not able to resolve this OAI Identifier to the repository landing page. If you are the repository manager for this record, please head to the Dashboard and adjust the settings.
Objective: Vitamin D plays an important role in mineral turnover and bone remodeling and there
are increasing data about its immunomodulatory potential in different rheumatologic disorders.
Deficiency of vitamin D is frequent in patients with spondyloarthritis (SpA) and some data suggest
its association with increased disease activity and structural damage. However, its exact role in the
pathogenesis of SpA and its association with disease activity are still a matter of debate.
Material and methods: A cross-sectional study of patients diagnosed with axial spondyloarthritis
(axSpA) and peripheral spondyloarthritis (perSpA) according to Assessment of Spondyloarthritis
International Society classification criteria was performed. The correlation between concentration
of 25-hydroxyvitamin D - 25(OH)D - and disease activity scores (Bath Ankylosing Spondylitis
Disease Activity Index - BASDAI, Ankylosing Spondylitis Disease Activity Score - ASDAS), inflammatory
markers (C-reactive protein - CRP, erythrocyte sedimentation rate - ESR) and clinical symptoms
(arthritis, enthesitis, dactylitis) was performed.
Results: We included 40 patients with axSpA and 23 patients with perSpA. The mean concentration
of 25(OH)D was 24.9 ng/ml (SD 12.49). Forty-seven (74.6%) patients had 25(OH)D below the
recommended threshold (< 30 ng/ml). We found no statistically significant negative correlation between
the level of 25(OH)D and disease activity of axSpA and perSpA in terms of clinical symptoms
(arthritis, enthesitis, dactylitis), inflammatory markers (ESR, CRP) and disease activity scores
(BASDAI, ASDAS). These results did not change after adjustment for supplementation of vitamin D
and seasonal variation.
Conclusions: Our data show no correlation between the concentration of 25(OH)D in the serum
and disease activity in two subgroups of SpA. However, this does not exclude the potential role of
vitamin D in pathogenesis of SpA. Further studies are required to evaluate the optimal range of
25(OH)D serum concentration in axSpA and perSpA patients with its possible immunomodulatory
potential and influence on disease activity
Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.