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Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs
Abstract
Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs.Proteomic- Article / Letter to editor
- info:eu-repo/semantics/article
- Text
- mass spectrometry biomarker MALDI-TOF SELDI-TOF colorectal cancer breast cancer screening proteomics magnetic beads enhanced laser-desorption flight mass-spectrometry fecal occult blood colorectal-cancer breast-cancer protein profiles plasma-proteome identification diagnosis mammography