Repository landing page
High-aspect-ratio nanostructured surfaces as biological metamaterials
Abstract
Materials patterned with high-aspect-ratio nanostructures have features on similar lengthscales to cellular components. These surfaces are an extreme topography on the cellular level and have become useful tools for perturbing and sensing the cellular environment. Motivation comes from the ability of high-aspect-ratio nanostructures to deliver cargoes into cells and tissues, access the intracellular environment, and control cell behavior. These structures directly perturb cells’ ability to sense and respond to external forces, influencing cell fate and enabling new mechanistic studies. Through careful design of their nanoscale structure, these systems act as biological metamaterials, eliciting unusual biological responses. While predominantly used to interface eukaryotic cells, there is growing interest in non-animal and prokaryotic cell interfacing. Both experimental and theoretical studies have attempted to develop a mechanistic understanding for the observed behaviors, predominantly focusing on the cell – nanostructure interface. Here, we consider how high-aspect-ratio nanostructured surfaces are used to both stimulate and sense biological systems and discuss remaining research questions- Journal Article
- Science & Technology
- Physical Sciences
- Technology
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Nanoscience & Nanotechnology
- Materials Science, Multidisciplinary
- Physics, Applied
- Physics, Condensed Matter
- Chemistry
- Science & Technology - Other Topics
- Materials Science
- Physics
- biological metamaterials
- high-aspect-ratio nanostructures
- nanoneedles
- nanopillars
- nanowires
- MESENCHYMAL STEM-CELLS
- OPTICAL RECONSTRUCTION MICROSCOPY
- VERTICALLY ALIGNED NANOWIRES
- SCANNING-ELECTRON-MICROSCOPY
- DIAMOND-NANONEEDLE-ARRAY
- LIQUID-SOLID MECHANISM
- SILICON NANOWIRES
- MEMBRANE CURVATURE
- LIVING CELLS
- INTRACELLULAR DELIVERY
- biological metamaterials
- high-aspect-ratio nanostructures
- nanoneedles
- nanopillars
- nanowires
- 02 Physical Sciences
- 03 Chemical Sciences
- 09 Engineering
- Nanoscience & Nanotechnology