Repository landing page
Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host
Abstract
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the role of a cross-reactive immune response in resolving an acute infection. We construct a mathematical model of within-host influenza viral dynamics including three possible factors which determine the strength of the cross-reactive cellular adaptive immune response: the initial naive T cell number, the avidity of the interaction between T cells and the epitopes presented by infected cells, and the epitope abundance per infected cell. Our model explains the experimentally observed shortening of a second infection when cross-reactivity is present, and shows that memory in the cellular adaptive immune response is necessary to protect against a second infection- Journal Article
- Science & Technology
- Life Sciences & Biomedicine
- Biology
- Mathematical & Computational Biology
- Life Sciences & Biomedicine - Other Topics
- Mathematical model
- Viral dynamics
- Immunology
- Cytotoxic T lymphocyte
- CD8 T-CELLS
- A VIRUS-INFECTION
- LYMPHOCYTIC CHORIOMENINGITIS VIRUS
- MATHEMATICAL-MODEL
- IN-VIVO
- ANTIGEN PRESENTATION
- POPULATION-DYNAMICS
- PANDEMIC INFLUENZA
- VIRAL-INFECTION
- NAIVE
- Cytotoxic T lymphocyte
- Immunology
- Mathematical model
- Viral dynamics
- Adaptive Immunity
- CD8-Positive T-Lymphocytes
- Cross Reactions
- Epitopes
- Host-Pathogen Interactions
- Humans
- Immunity, Cellular
- Immunologic Memory
- Influenza, Human
- Models, Immunological
- Viral Load
- CD8-Positive T-Lymphocytes
- Humans
- Epitopes
- Viral Load
- Cross Reactions
- Immunity, Cellular
- Immunologic Memory
- Models, Immunological
- Influenza, Human
- Host-Pathogen Interactions
- Adaptive Immunity
- Science & Technology
- Life Sciences & Biomedicine
- Biology
- Mathematical & Computational Biology
- Life Sciences & Biomedicine - Other Topics
- Mathematical model
- Viral dynamics
- Immunology
- Cytotoxic T lymphocyte
- CD8 T-CELLS
- A VIRUS-INFECTION
- LYMPHOCYTIC CHORIOMENINGITIS VIRUS
- MATHEMATICAL-MODEL
- IN-VIVO
- ANTIGEN PRESENTATION
- POPULATION-DYNAMICS
- PANDEMIC INFLUENZA
- VIRAL-INFECTION
- NAIVE
- q-bio.PE
- q-bio.PE
- q-bio.CB
- 92C60, 92D30
- Evolutionary Biology
- 01 Mathematical Sciences
- 06 Biological Sciences
- 08 Information and Computing Sciences